Q – What is Celadrin® made from?

A – Celadrin® is made from a patented complex blend of special esterified fatty acids, derived from bovine tallow oil.

Q – Is Celadrin® Safe?

A – Celadrin® is a very safe mix of fatty acids with no known or reported negative reactions or side effects. The esterification process takes place at extremely high temperatures (over 500 degrees Fahrenheit). Scientific Acute Toxicity and Ames test screening have validated its safety. Over 100 million Celadrin® pills have been distributed to date.

Q – How does Celadrin® work?

A – Celadrin® decreases inflammation and lubricates cell membranes throughout the body, restoring fluids that cushion bones and joints to promote flexibility and mobility. Over time, because of the reduction of inflammation delivered by using Celadrin®, the joints and surrounding tissue have an opportunity to promote healthy joints.

Celadrin® works similar to, but much more dramatically than the essential fatty acids EPA and DHA from fish oils. Celadrin’s complex blend of esterified fatty acids; provide many vital and beneficial effects for the inflammatory responses in the body. Celadrin® induces changes at the cellular level, in the cell membranes which positively affect the responsiveness of the cell membranes. This aids in the reduction of cartilage breakdown in the joints.

Q – Is their any science behind Celadrin®?

A – Celadrin® has been clinically studied at various times with results published in the prestigious Journal of Rheumatology for both oral and topical applications as well as the Journal of Strength and Conditioning Research.

For oral application, Celadrin® was studied using a double-blind, multi-center, placebo-controlled trial (the most scientifically validated type). Sixty-four participants between the ages of 37 to 77 were given Celadrin® capsules and were evaluated at the beginning of the trial, at 30 days and at the end of the 68 day study. Compared to those given a placebo, those who were given Celadrin® had more flexibility, fewer aches, less pain and were able to walk further distances than the placebo group. The study therefore concluded that Celadrin®, when taken orally improved joint and mobility problems.

For topical application of Celadrin® cream, a study was conducted at the University of Connecticut, involving 42 patients with osteoarthritis of the knee. Participants used either Celadrin® or a placebo cream. Patients were evaluated before application of the cream, 30 minutes after, and then again following a 30 day treatment period during which the cream was applied twice a day, morning and evening. The researchers evaluated physical function, postural movement, pain and range of motion. The test included how long it took the patient to get up and go from a chair, stair climbing, endurance, and mobility of the knee. The group receiving Celadrin® had outstanding results with reduced pain and stiffness, improved balance and strength and better mobility. 100% of the patients in the study showed significant benefit compared to the patients on the placebo. Even more exiting was that patients experienced a dramatic improvement in all aspects tested after only 30 minutes of applying the cream with cumulative benefits occurring after 30 days.

An additional study, as an extension of this original study, confirmed earlier research showing improvement in elbow, wrist and knee mobility and significant reduction in pain.

Q – Which is better, Celadrin® cream or Celadrin® pills?

A – Both oral and topical applications were shown to be equally effective in a separate study, where it was proven that the Esterified Fatty Acids (EFAC) found in Celadrin®, could be absorbed by either method (95.1% absorption rate proven through a University of Minnesota labeled study) into the body.

Q – How would you compare Vioxx and other Cox 2 – Inhibitors to Celadrin®?

A - Vioxx works as a Cox-2 inhibitor, which causes numerous side effects - including upper and lower G.I. bleeding amongst other even more serious side effects. The whole class of Cox-2 inhibitors raises doubts about their safety. These drugs were supposed to offer the pain killing features of aspirin without damage to the stomach lining.

When taking Vioxx or other Cox-2s one only receives pain relief for a short period of time. Celadrin® helps relieve the stiffened membrane caused by aging, inflammation and other assaults. Restoration and joint health begins with Celadrin® where it has immediate and cumulative benefits, with no negative side effects. Safety profile of Celadrin® is impeccable. With Celadrin® one is better off tomorrow and the next day than they are today – it just gets better every day as Celadrin® addresses causation not just the symptoms.

Celadrin® works on the cell membrane to allow rapid healing - you don't even need glucosamine to repair cartilage, Celadrin® provides the healing of the joint and surrounding tendons and tissues. One does not need the matrix of the bone to repair a broken arm - but with Celadrin® even that broken arm will be repaired faster - naturally.

In summary, all Cox-2s inherently have serious and numerous side effects - particularly when taken daily.

Q – How does Celadrin® compare to other natural joint health products?

A - Celadrin's beneficial effects have been proven superior in results to Glucosamine, Chondroitin, MSM, SAMe and other natural joint health products.

Celadrin® provides restoration of a wide range of joint health conditions including sports injuries to joints, muscles, tendons and deep tissue.

Q – Can Celadrin® work well in conjunction to taking Glucosamine?

A - The cause of wear on the joint area can be attributable to inflammation as well as insufficient lubrication and cell membrane fluidity. Glucosamine assists in the rebuilding of cartilage & the overall structure of the joint and has shown moderate effects on people with osteoarthritis. Celadrin® provides continuous lubrication and allows the cell membrane to repel inflammatory chemicals. Celadrin® stops the cascade of inflammation and the assaults on the membrane which cause it to stiffen. Celadrin ® empowers glucosamine to perform faster and more efficiently in building joint cartilage as well as accelerating and promoting joint health. The dual action of Celadrin® and glucosamine provide rapid joint cushioning, quickly alleviate inflammation, build cartilage and restore the entire joint area.

Q – Does Celadrin replace fish oils?

A - Although Celadrin is a fatty acid it does not replace the need for Omega 3 fatty acids from fish oils or flaxseed oil. They are complementary and can be taken together; each having their own beneficial action.

Q - Does Celadrin work like Vioxx and Celabrex?

A - No synthetic Cox-2 inhibitors are very specific. In addition to producing inflammatory agents in the body, Cox-2 is required in the manufacture of prostacyclin a very positive prostaglandin. Because Cox-2 uses up this protective prostaglandin this is likely the reason behind its negative effects. Celadrin does not affect prostacylcin and therefor provides a safe, non-toxic anti-inflammatory action.

Q - Can I take Celadrin with Coumadin (Warfarin)?

A - The most common question received by the Celadrin website is about the use of Coumadin or Warfarin and Celadrin. Celadrin is a combination of fatty acids. The Physician's Desk Reference (PDR) provides the following advice regarding herb and nutrient consumption while taking Coumadin or Warfarin. As you can see from the information directly from the PDR, fatty acids are not included in the list of nutrients to be avoided. The list of those that should be avoided or not to be started once you are on anti-coagulant drugs includes bromelain, coenzyme Q10, danshen, dong quai, garlic, Ginkgo biloba, ginseng and St. John's Wort and vitamin E and vitamin K. As per the PDR none of the fatty acids (fish oil, Evening Primrose oil, Borage, Cetylated fatty acids, olive oil, are not included.

(FROM the PDR)
Information for Patients: The objective of anticoagulant therapy is to decrease the clotting ability of the blood so that thrombosis is prevented, while avoiding spontaneous bleeding. Effective therapeutic levels with minimal complications are in part dependent upon cooperative and well-instructed patients who communicate effectively with their physician. Patients should be advised: Strict adherence to prescribed dosage schedule is necessary. Do not take or discontinue any other medication, including salicylates (e.g., aspirin and topical analgesics), other over-the-counter medications, and botanical (herbal) products (e.g., bromelains, coenzyme Q 10 , danshen, dong quai, garlic, Ginkgo biloba, ginseng, and St. John's wort) except on advice of the physician. Avoid alcohol consumption. Do not take COUMADIN during pregnancy and do not become pregnant while taking it (see CONTRAINDICATIONS ). Avoid any activity or sport that may result in traumatic injury. Prothrombin time tests and regular visits to physician or clinic are needed to monitor therapy. Carry identification stating that COUMADIN is being taken. If the prescribed dose of COUMADIN is forgotten, notify the physician immediately. Take the dose as soon as possible on the same day but do not take a double dose of COUMADIN the next day to make up for missed doses. The amount of vitamin K in food may affect therapy with COUMADIN. Eat a normal, balanced diet maintaining a consistent amount of vitamin K. Avoid drastic changes in dietary habits, such as eating large amounts of green leafy vegetables. Contact physician to report any illness, such as diarrhea, infection or fever. Notify physician immediately if any unusual bleeding or symptoms occur. Signs and symptoms of bleeding include: pain, swelling or discomfort, prolonged bleeding from cuts, increased menstrual flow or vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or dark brown urine, red or tar black stools, headache, dizziness, or weakness. If therapy with COUMADIN is discontinued, patients should be cautioned that the anticoagulant effects of COUMADIN may persist for about 2 to 5 days. Patients should be informed that all warfarin sodium, USP, products represent the same medication, and should not be taken concomitantly, as overdosage may result.